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Discovery Antibodies/(S)(-)-Bay K8644/1 mg/B-351-1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Discovery Antibodies/(S)(-)-Bay K8644/1 mg/B-351-1 mg

Cat#:B-351
  • LyophilizedPowder
  • BioassayTested
    • SourceSynthetic
    MW:356.3
    Purity:>98%(HPLC)
    FormLyophilizedpowder.
    Effectiveconcentration50nM-5µM.
      • (S)(-)-Bay K8644
    Chemicalname(4S)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylicacidmethylester.
    MolecularformulaC16H15 F3N2O4.
    CASNo.:98625-26-4.
    Activity(S)(-)-BayK8644isanL-typeCa2+-channelactivator. Itdisplaysvasoconstrictiveeffects invivo1.
      • Franckowiak,G. etal. (1985) Eur.J.Pharmacol. 114, 223.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    Solubility100mMinDMSO.Centrifugeallproductpreparationsbeforeuse(10000xgfor1min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
      • (S)(-)-Bay K8644
        AlomoneLabs(S)(-)-BayK8644increasesL-typeCaV channelcurrentsheterologouslyexpressedin Xenopus oocytes.
        A.TimecourseofCaV1.2(co-expressedwithα2δ1andβ1auxiliarysubunits)peakcurrentamplitude,elicitedby100msvoltagerampfromholdingpotentialof-100mVto+50mV,deliveredevery10seconds.Applicationof0.1and1µM (S)(-)-BayK8644 (#B-351)increasestheCaV1.2current(indicatedbythehorizontalbar).B.Representativecurrenttracesbeforeandduringapplicationof0.1and1µM(S)(-)-BayK8644asindicated.
    References-Scientificbackground
    • 1.Hadley,R.W.andHume,J.R. (1988) Circ.Res. 62, 97.
    • 2.Wei,X.Y. etal. (1986) J.Pharmacol.Exp.Ther. 239, 144.
      • (S)(-)-BayK8644isanL-typeCa2+-channelactivatorwithpositiveinotropic,vasoconstrictiveandbehavioraleffectsinvivo.Itisanenantiomerof(±)-BayK8644.(S)(-)-BayK8644isadihydropyridinethatcan,amongothereffects,constrictbloodvesselsandincreasetheforceofcontractionoftheheart.ThedrugisthoughttoincreasetheentryofCa2+intocellsbyincreasingtheopen-stateprobABIlityofCa2+channels,eitherbyprolongingthedurationofindividualopeningsorbyincreasingthenumberofopenings.ItwasnotedinearlyexperimentswithBayK8644thatthedose-responsecurveisbiphasic1.Theactionof(S)(-)-BayK8644wasstudiedinrattailarteryandguineapigileallongitudinalsmoothmuscleusingpharmacologicandrADIoligandbindingassays.Itinducedconcentration-dependentcontractionsinbothsmoothmusclepreparationswithEC50valuesof1.98-11nM.Withincreasingconcentrations,(S)(-)-BayK8644relaxedthetissuewithIC50valuesof0.53-2.60μM2.
    TargetL-typeCa2+ channels
    LyophilizedPowder
    receivea1mgfreetrialsample!
    Lastupdate:24/09/2019

    (S)(-)-BayK8644(#B-351) isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
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