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Discovery Antibodies/Anti-Neurokinin 1 Receptor (NK1R) (extracellular)-FITC Antibody/50 µl/ATR-001-F-50 µl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Discovery Antibodies/Anti-Neurokinin 1 Receptor (NK1R) (extracellular)-FITC Antibody/50 µl/ATR-001-F-50 µl

Cat#:A-155
AlternativeNameAnnoyltin®,Tryptizol®,Domical®,Elavilhydrochloride®,Amavil®,Saroten®,Ami-Anelun®,Lentizol®
  • LyophilizedPowder
  • BioassayTested
    • SourceSynthetic
    MW:313.86
    Purity:>99%
    Effectiveconcentration1-100µM.
      • Amitriptyline hydrochloride
    Chemicalname3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanaminehydrochloride.
    MolecularformulaC20H24ClN.
    CASNo.:549-18-8.
    ActivityInhibitorofSEROtoninandnoradrenalinuptake.Alsoactivatesα2A-adrenoceptorsandantagonizes5-HT2receptors.Displaysantinociceptiveactivity1.
      • Wu,W. etal. (2012) Neurosci.Lett. 506, 307.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    SolubilityDMSO.Centrifugeallproductpreparationsbeforeuse(10000xg5min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
      • Amitriptyline hydrochloride
        AlomoneLabsAmitriptylinehydrochlorideinhibitsL-typevoltage-gatedCa2+ currentsexpressedin Xenopus oocytes.
        A.TimecourseofCaV1.2/α2-δ1/β1currentinhibitionby800µM Amitriptyline hydrochloride(#A-155).Currentswereelicitedbyapplicationofvoltagerampsfromaholdingpotentialof-100mVto+50mV(100msec).B.Superimposedexampletracesofcurrentresponsesbeforeandduringperfusionof800µMAmitriptylinehydrochloride,asindicated.
    References-Scientificbackground
    • 1.Soldatov,N.M. (2012) ISRNMol.Biol. 2012,691341.
    • 2.Haderer,A. etal. (2003) Anesth.Analg. 96, 1707.
    • 3.Baldessarini,R.J. etal.(1995) ThePharmacologicalBasisofTherapeutics 431.
    • 4.Bryson,H.M.and Wilde,M.I. (1996) DrugsAging 8, 459.
    • 5.Zahradník,I. etal.(2008) J.Pharmacol.Exp.Ther. 324, 977.

      • Voltage-gatedL-typeCaV1.2calciumchannelscouplemembranedepolarizationtotransientincreaseincytoplasmicfreeCa2+concentrationthatinitiatesanumberofessentialcellularfunctionsincludingcardiacandvascularmusclecontraction,geneexpression,neuronalplasticity,andexocytosis1.

        Tricyclicantidepressants(TCAs)areknowntoinhibitCa2+currents,includingtheL-typeCaV1.2channelinheartmyocyteandneurons2.Otherknownphysiologicaltargetsoftricyclicantidepressantsinthecentralnervoussystemarethe5-HT2serotoninreceptorsandtheα1-adrenergicreceptors3.

        Amitriptylinehydrochloride,atricyclicantidepressant,isusedforanumberofmedicalconditionsincludingmanagementofdepressive,anxietyandbipolardisorders3andmanagementofchronicpainsuchasneuropathicpain,diabeticneuropathy,postherpeticneuralgiaandfibromyalgia4.

        Theproposedmechanismsofactionforamitriptylinehydrochlorideincludeinhibitionofthereuptakeofserotoninandnorepinephrine,inhibitionofNMDAreceptors,ofvoltage-gatedionchannelssuchasCa2+andNa+channelsandinteractionwithadenosinereceptors5.

    TargetL-typeCa2+channels,α-adrenergicreceptors,5-HT2serotoninreceptors
    LyophilizedPowder
    receivea10gfreetrialsample!
    Lastupdate:22/09/2019

    Amitriptylinehydrochloride(#A-155) isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
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