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Discovery Antibodies/A23187/10 x 1 mg/A-600-10 x 1 mg

Cat#:A-600
AlternativeNameCalcimycin,Calcium ionophoreA23187
  • LyophilizedPowder
  • BioassayTested
    • OriginStreptomyceschartreusis.
    SourceNatural
    MW:523.6
    Purity:>98%
    Effectiveconcentration1-10µM.
      • A23187
    Chemicalname5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylicacid.
    MolecularformulaC29H37N3O6.
    CASNo.:52665-69-7.
    ActivityA23187isamobile-carrierCa2+ionophoreandcancausecellactivation,differentiation,orproliferationandthusmimicscellularprocessesobservedinresponsetocytokinesandgrowthfactors1,2.FurThermore,A23187induces,inaconcentration-andtime-dependentmanner,Ca2+triggeredcellapoptosis3,4.
      • Berridge,M.J. (1993) Nature 361,315.
      • Scharff,O. etal.(1993) Physiol. Rev. 73,547.
      • Orrenius,S. etal. (2003) Nat.Rev.Mol.CellBiol. 4,552.
      • Hajnoczky,G. etal. (2003) Biochem.Biophys.Res.Commun. 304,445.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    SolubilityDMSO,ethanolormethanol.Centrifugeallproductpreparationsbeforeuse(10000xg5min).
    StorageofsolutionsUptooneweekat4°Corthreemonthsat-20°C.
    Protectfromlight.
      • A23187
        AlomoneLabsA23187inducesapoptosisinJurkatcells.
        2µM A23187 (#A-600)orvehiclewasaddedtotheconfluentcellculturefor6hours.ApoptosiswasprobedbythedetectionofcleavedCaspase3usingCaspase3specificantibodiesinwesternblotanalysisofcelllysates.
    References-Scientificbackground
    • 1.Berridge,M.J. (1993) Nature 361,315.
    • 2.Scharff,O. etal. (1993) Physiol.Rev. 73,547.
    • 3.Orrenius,S. etal. (2003) Nat.Rev.Mol.CellBiol. 4,552.
    • 4.Hajnoczky,G. etal. (2003) Biochem.Biophys.Res.Commun. 304,445.
    • 5.Caron-Leslie,L.A. etal. (1991) Mol.Endocrinol. 5,1169.
    • 6.Caron-Leslie,L.A. etal. (1994) FASEBJ. 8,639.
    • 7.Rzigalinski,B.A. etal. (1994) Biochim.Biophys.Acta. 1223,219.
    • 8.Vrana,J.A. etal. (1998) Int.J.Oncol. 12,927.
    • 9.Petersen,A. etal. (2000) BrainRes. 857,20.
    • 10.Cheng,C.H. etal. (2002) FEBSLett. 516,191.
    • 11.Jansen,S. etal. (2003) Biol.TraceElem.Res. 96,133.

      • A23187isamobile-carrierCa2+ionophore(allowsCa2+ionstocrosscellmembranes)originallyisolatedasanantibioticfromStreptomyceschartreusensis.ItisusedtoincreaseintracellularCa2+levelsandforinvitrostudiesrelatedtointracellularCa2+-mediatedevents.A23187cancausecellactivation,differentiation,orproliferationandthusmimicscellularprocessesobservedinresponsetocytokinesandgrowthfactors.1,2

        Furthermore,A23187induces,inaconcentration-andtime-dependentmanner,Ca2+-triggeredcellapoptosis.3,4Thispropertywasexploitedtoclarifyapoptoticeventsindifferentcelllinessuchasmouselymphomacellline(S49),5,6histiocyticlymphomaU937,7humanmyeloidleukemiacells(HL-60),8culturedstriatalneurons,9renaltubularcells,10andC6gliomacells.11

    LyophilizedPowder
    receivea1mgfreetrialsample!
    Lastupdate:25/09/2019

    A23187(#A-600) isahighlypure,natural,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
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