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Discovery Antibodies/Orphenadrine citrate salt/5 g/O-100-5 g188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Discovery Antibodies/Orphenadrine citrate salt/5 g/O-100-5 g

Cat#:O-100
AlternativeNameNorflex®,Banflex®,Flexon®,X-Otag®
  • LyophilizedPowder
  • BioassayTested
    • SourceSynthetic
    MW:461.5
    Purity:>96%
    Effectiveconcentration0.3-100µM.
      • Orphenadrine citrate salt
    Chemicalnameβ-Dimethylaminoethyl2-methylbenzhydrylethercitratesalt.
    MolecularformulaC18H23NO●C6H8O7.
    CASNo.:4682-36-4.
    ActivityOrphenadrinewasfoundtoactasmuscarinicreceptorantagoNIST,H1 histaminereceptorantagonist,musclerelaxant,inhibitorofthenoradrenergictransporter,NMDAreceptorantagonistandNaV channelblocker1-4.
      • Brocks,D.R. etal. (1999) J.Pharm.Pharm.Sci. 2, 39.
      • Desaphy,J.F. etal. (2009) Pain 142, 225.
      • Kornhuber,J. etal. (1995) J.Neural.Transm.Gen.Sect. 102, 237.
      • Pubill,D. etal. (1999) J.Pharm.Pharmacol. 51, 307.
    ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
    SolubilityDMSO.Centrifugeallproductpreparationsbeforeuse(10000xg5min).
    StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
      • Orphenadrine citrate salt
        AlomoneLabs Orphenadrinecitratesalt inhibitscharbacol-induced Ca2+ signalin C6cellsexpressingM1muscarinicreceptor.
        ChangesinintracellularCa2+ weredetectedviachangesinFluo-3emissionfollowingapplication.A.Normalizedfluorescencebeforeandafterco-application(at20seconds,seearrow)of10µMcarbacholand0-100µM Orphenadrinecitratesalt (#O-100)asindicated.B.Inhibition(aspercentofcontrol)of10µMcarbacholevokedCa2+ rise,plottedagainstOrphenadrinecitratesaltconcentrations.
    References-Scientificbackground
    • 1.Brocks,D.R. etal. (1999) J.Pharm.Pharm.Sci. 2, 39.
    • 2.Desaphy,J.F. etal. (2009) Pain 142, 225.
    • 3.Kornhuber,J. etal. (1995) J.Neural.Transm.Gen.Sect. 102, 237.
    • 4.Pubill,D. etal. (1999) J.Pharm.Pharmacol. 51, 307.

      • Thegroupofanticholinergicdrugsincludesbenztropine,biperiden,diphenhydramine,ethopropazine,orphenadrine,procyclidineandtrihexyphenidyl.OrphenadrineasthecitratesaltisusedforthetreatmentofParkinson’sdiseaseandinmusculoskeletaldisorders.Itisalsousedasananalgesic,althoughitsmechanismofactionisstillunknown1,2.Orphenadrinebindstoandmodulatestheactivityofmuscarinicreceptorsofratbrain,withIC50of0.37µM1.

        OrphenadrineinhibitsNaVchannelsinaconcentration-,voltage-andfrequency-dependentmannerbybindingtothesamereceptorasthelocalanesthetics2.Orphenadrinewasreportedasamuscarinicreceptorantagonist,H1histaminereceptorantagonist,musclerelaxant,andinhibitsthenoradrenergictransporterandblockstheNMDAreceptorionchannel3,4.

    TargetMuscarinic,H1histamine,NMDAreceptors,NaV Na+ channels
    LyophilizedPowder
    receivea1gfreetrialsample!
    Lastupdate:26/09/2019

    Orphenadrinecitratesalt(#O-100) isahighlypure,synthetic,andbiologicallyactivecompound.

    Forresearchpurposesonly,notforhumanuse
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