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| ProductName | Lelch-likeECH-associatedprotein1,KEAP1 |
| Size | 100µg |
| Description | Keap1hasfourdiscreteproteindomains.TheN-terminalBroadcomplex,TramtrackandBric-à-Brac(BTB)domaincontainstheCys151residue,whichoneoftheimportantcysteinesinstresssensing.Theinterveningregion(IVR)domaincontainstwocriticalcysteineresidues,Cys273andCys288,whichareasecondgroupofcysteinesimportantforstresssensing.Adoubleglycinerepeat(DGR)andC-terminalregion(CTR)domainscollaboratetoformaβ-propellerstructure,whichiswhereKeap1interactswithNrf2. Keap1hasbeenshowntointeractwithNrf2,amasterregulatoroftheantioxidantresponse,whichisimportantfortheameliorationofoxidativestress.Underquiescentconditions,Nrf2isanchoredinthecytoplasmthroughbindingtoKeap1,which,inturn,facilitatestheubiquitinationandsubsequentproteolysisofNrf2.SuchsequestrationandfurtherdegradationofNrf2inthecytoplasmaremechanismsfortherepressiveeffectsofKeap1onNrf2. BecauseNrf2activationleadstoacoordinatedantioxidantandanti-inflammatoryresponse,andKeap1repressesNrf2activation,Keap1hasbecomeaveryattractivedrugtarget.Syntheticoleanetriterpenoidcompounds,knownasantioxidantinflammationmodulators(AIMs)havebeenshowntoblockKeap1-dependentNrf2ubiquitinationandleADIngtothestABIlizationandnucleartranslocationofNrf2andsubsequentinductionofNrf2targetgenes. |
| Source | baculovirus/sf9cells |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 9817 |
| Accession# | NM_000546 |
| GeneName | kelch-likeECH-associatedprotein1 |
| GeneSymbol | KEAP1 |
| GeneSynonyms | INrf2;KLHL19 |
| MW | 69.6kDa |
| ProteinSequence | 1MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT |
| StorageBuffer | 20mMTris-Cl(pH8.0),50%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
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