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Bpsbioscience/AMPK (A2/B1/G1), Histags/40024/10 µg
Species:Human
HostSpecies:Sf9insectcells
MW:~147kDa(complex)
Genbank#:NM_006252(A2),NM_006253(B1),NM_002733(G1)
Tag(s):C-terminalHis-tags
a.a:fulllength
Background:
AMPK(A2/B1/G1)playsakeyroleininsulinsignalingpathwayandisamajortherapeutictargetforthetreatmentofdiabetes(1).AMPKisviewedasafuelsensorforglucoseandlipidmetabolismbymodulatingtheactivityoftheautonomousnervoussysteminvivo.Short-termoverexpressionofaconstitutivelyactiveformofAMPKintheliverleadstomildhypoglycemiaandfattyliverduetoincreasedfattyacidutilization(2).
Description:
RecombinanthumanAMPK(combinationofA2/B1/G1subunits),fulllength,withC-terminalHis-tag,expressedinSf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
SubunitA2:PRKAA2,AMPK,AMPK2,PRKAA
SubunitB1:PRKAB1,AMPK,HAMPKb,MGC17785
SubunitG1:PRKAG1,AMPKG,MGC8666
Purity:
≥75%
Formulation:
50mMsodiumphosphate,pH7.0,300mMNaCl,150mMimidazole,0.1mMPMSF,0.25mMDTT,25%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:

>6monthsat-80°C.

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Viollet,B.etal:PhysiologicalroleofAMP-activatedproteinkinase(AMPK):insightsfromknockoutmousemodels.Biochem.Soc.Trans.2003;31;216–219.
2.Foretz,M.etal:Short-termoverexpressionofaconstitutivelyactiveformofAMP-activatedproteinkinaseintheliverleadstomildhypoglycemiaandfattyliver.Diabetes,2005;54(5);1331-1339.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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