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Bpsbioscience/PRMT6 (HRMT1L6), His-tag/51049/20 µg

Species:Human
HostSpecies:E.coli
MW:43kDa
Genbank#:NM_018137
Tag(s):N-terminalHis-tag
a.a:2–375(end)
Background:
Argininemethyltransferasethatcanbothcatalyzetheformationofmonomethylarginine(MMA)andasymmetricaldimethylarginine(aDMA),withastrongpreferencefortheformationofaDMA.Preferentiallymethylatesarginylresiduespresentinaglycineandarginine-richdomainanddisplayspreferenceformonomethylatedsubstrates.SpecificallymediatestheasymmetricdimethylationofhistoneH3Arg-2toformH3R2me2a.H3R2me2arepresentsaspecifictagforepigenetictranscriptionalrepressionandismutuallyexclusivewithmethylationonhistoneH3Lys-4(H3K4me2andH3K4me3).IttherebyactsasatranscriptioncorepressorofvariousgenessuchasHOXA2.AlsomethylateshistoneH2AandH4Arg-3(H2AR3meandH4R3me,respectively).ActsasaregulatorofDNAbaseexcisionduringDNArepairbymediatingthemethylationofDNApolymerasebeta(POLB),leADIngtostimulatethepolymeraseactivitybyenhancingDNAbindingandprocessivity.MethylatesHMGA1.MayplayaroleininnateimmunityagainstHIV-1incaseofinfectionbymethylatingandimpairingthefunctionofvariousHIV-1proteinssuchasTat,RevandNucleocapsidproteinp7(NC).
Description:
HumanPRMT6(GenBankAccessionNo.NM_018137),a.a.2-375(end),withN-terminalHis-tag,MW=43kDa,expressedinE.coli.
UniProt
Q96LA8
Synonym(s):
PRMT6,HRMT1L6,proteinarginineN-methyltransferase6
SpecificActivity:
0.015pmol/min/µg 
AssayConditions:
50µlreactionmix(20mMphosphatebufferpH7.4,20µMS-adenosylmethionine,and1-5ngmethyltransferasePRMT6)isaddedtomicrowellscoatedwithhistonesubstrate.Incubateat30°Cfor2hr.AddantibodyagainstmethylatedArgresidueofhistoneH3,incubate1hr.Then,addsecondaryHRP-labeledantibodyandincubate30min.Finally,addHRPchemiluminescentsubstratesandreadluminesence.
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,3mMDTT,20%glycerol,and200mMimidazole
Format:
Aqueousbuffersolution
Storage/StABIlity:

>6monthsat-80°C.

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.HyllusD.etal.,J.GenesDev.21(24),3369-3380(2007).
2.GuccioneE.etal.,Nature449(7164),933-937(2007).
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Methyltransferase
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
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