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Bpsbioscience/MuRF3, SUMOHistags/81054/25 µg
Species:Human
HostSpecies:E.coli
MW:40.3kDa(withoutSUMOtag)
Genbank#:Q9BYV2
Tag(s):N-terminalSUMO-His-tags
a.a:fulllength
Background:
MuRF3isaRINGdomainE3ligasethatisinvolvedintheconjugationofubiquitintotargetsubstrates.MuRF3hasbeendemonstratedtofunctionwiththeE2enzymeUBE2D3(UbcH5c)invitro.MuRF3isalsoknownasTRIM54(tripartitemotifcontaining54)containingaRING-finger/B-box/coiled-coiltripartitefold.MuRF3hasbeenimplicatedalongwithMuRF1asregulatorsofproteindegradationinstriatedmuscle.MuRF3alsoplaysimportantrolesinmaintainingcardiacfunctionaftermyocardialinfarction.
Description:
HumanMuRF3recombinantprotein(GenbankAccessionNo.Q9BYV2),fulllengthwithN-terminalSUMO-andHis-tags,expressedinE.coli.
UniProt
Q9BYV2
Synonym(s):
E3ubiquitin-proteinligaseTRIM54,MURF3,MuRF-3,MURF-3,Muscle-specificRINGfingerprotein3,RINGfingerprotein30,RNF30,Tripartitemotif-containingprotein54
Purity:
≥90%bySDS-PAGE
BIOLOGicalActivity:
Typicalenzymeconcentrationof20-1000nMisusedforinvitroconjugationdependingonassayconditions.
Formulation:
50mMTrisBuffer,pH7.6,150mMNaCl,10%glycerol
Format:
Aqueousbuffersolution
Storage/StABIlity:

Stablefor≥1yearat–80°C.

Application(s):
UsefulasanE3ligaseinubiquitin-conjugatingreactionsandtoanalyzeupregulation/downregulationofE3enzymes.
Reference(s):
1.Balasubramanian,S.,etal.EnhancedubiquitinationofcytoskeletalproteinsinpressureoverloadedmyocardiumisaccompaniedbychangesinspecificE3ligases.J.Mol.CellCardiol.,2006.41(4):p.669-79.
2.Fielitz,J.,etal.MyosinaccumulationandstriatedmusclemyopathyresultfromthelossofmuscleRINGfinger1and3.J.Clin.Invest.,2007.117(9):p.2486-95.
3.Fielitz,J.,etal.Lossofmuscle-specificRING-finger3predisposesthehearttocardiacruptureaftermyocardialinfarction.Proc.Natl.Acad.Sci.USA,2007.104(11):p.4377-82.
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Ubiquitination(UbiquitinLigase(E3))
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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