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Bpsbioscience/Geldanamycin/27008/5 mg
MW:560.6Da
CASRegistry#:30562-34-6
Formula:C29H40N2O9
Description:
Geldanamycinisanantibioticandapotentantitumorcompound.Itinhibitspp60srctyrosinekinase,anditalsobindsspecificallytoheatshockproteinHsp90anditsGP96homologue.Itisknowntoinhibitproteinmaturation.
Purity:

≥95%byHPLC.

BIOLOGicalActivity:
GeldanamycinstronglyinhibitedHsp90proteinasshownthroughinhibitedPlasmodiumfalciparumgrowthinhumanerythrocyteculturewithanIC50of20nM.
Solubility:
SolubleinanhydrousDMSOat100mg/ml.Poorlysolubleinmethanol.Ethanolandwaterarenotrecommendedforstocksolutions.Themaximumwatersolubilityisestimatedtobe~20–50µM.
Format:
Yellowcrystallinesolid;granularorpowder.
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Geldanamycinisunstableinwaterandethanol.DoesnotreactwithDMSO,butDMSOcancontainmoisturefromtheairand/orsmallamountsofDMSOdegradationproductsthatmightreact.KeepDMSOstocksolutionsoutofcontactwithair.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Whitesell,L.andCook,P.Mol.Endocr.10:705–712(1996)
2.Rajinder,K.,etal.,MalariaJournal2:30(2003)
Warning(s):
Protectfromairandmoisture.
ScientificCategory:
HeatShockProtein
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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