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Bpsbioscience/WntC59/277802/50 mg
MW:379.5Da
CASRegistry#:1243243-89-1
Formula:C25H21N3O
Target:Porcupine
Background:
Wnt-C59preventspalmitoylationofWntproteinsbyPorcupine(amembrane-boundO-acyltransferase),therebyblockingWntproteinsecretionandactivity,similartoWntinhibitorsIWP-2,IWP-3andIWP-4.ButWnt-C59ismorepotentandselective,andhasbetterchemical/physicalproperties,andismoresuitableforinvitro/invivostudies.
Description:
Wnt-C59isaverypotentandhighlyselectiveWntsignalingantagonistwithanIC50~74pMintheWntsignalingreporterassay.
Synonym(s):
2-[4-(2-Methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide
Solubility:
SolubleinDMSO
Storage/Stability:

Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.

Reference(s):
ProffittKD,etal.CancerRes.2013Jan15;73(2):502-7.
ScientificCategory:
WntSignaling
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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