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Bpsbioscience/Mouse MEK1 (EE), GSTtag/40121/10 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Bpsbioscience/Mouse MEK1 (EE), GSTtag/40121/10 µg
Species:Mouse
HostSpecies:E.coli
MW:69kDa
Genbank#:NM_008927
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
MEK1(EE)isamemberofthedualspecificityproteinkinasefamilythatactsasamitogen-activatedproteinkinase(MAPK)kinase.MEK1liesupstreamofMAPK/ERKandstimulatestheenzymaticactivityofMAPK/ERKuponawidevarietyofextra-andintracellularsignals.AsanessentialcomponentofMAPK/ERKsignaltransductionpathway,MEK1isinvolvedinmanycellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment(1).ConstitutiveactivationofMEK1resultsincellulartransformation.Thus,MEK1representsalikelytargetforpharmacologicinterventioninproliferativediseasesuchascancer(2).
Description:
RecombinantmouseMEK1(S218E,S222E),fulllengthwithSerinetoGlutamicacidmutationsona.a.218and222andanN-terminalGST-tag,expressedinE.colicells.
Synonym(s):
MAP2K1;MKK1;MAPKK1;PRKMK1;mitogenactivatedproteinkinasekinase
Purity:
≥95%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/Stability:

>6monthsat-80°C.

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Seger,R.etal:TheMAPKsignalingcascade.FASEBJ.9:726-735,1995.
2.Sebolt-Leopold,JS.etal:BlockadeoftheMAPkinasepathwaysuppressesgrowthofcolontumorsinvivo.NatureMed.5:810-816,1999.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Dual
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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