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Bpsbioscience/MEK1, GSTtag/40123/10 µg
Species:Human
HostSpecies:Sf9insectcells
MW:72kDa
Genbank#:NM_002755
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
MEK1isamemberofthedualspecificityproteinkinasefamilythatactsasamitogen-activatedproteinkinase(MAPK)kinase.MEK1liesupstreamofMAPK/ERKandstimulatestheenzymaticactivityofMAPK/ERKuponawidevarietyofextra-andintracellularsignals.AsanessentialcomponentofMAPK/ERKsignaltransductionpathway,MEK1isinvolvedinmanycellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment(1).ConstitutiveactivationofMEK1resultsincellulartransformation.Thus,MEK1representsalikelytargetforpharmacologicinterventioninproliferativediseasesuchascancer(2).
Description:
RecombinanthumanMEK1,alsoknownasMAP2K1(MAP[Mitogen-ActivatedProtein]KinaseKinase1),MKK1,orERKkinase,GenBankAccession#NM_002755,fulllength,withanN-terminalGST-tag,MW=74kDa,expressedinSf9cellsviaabaculovirusexpressionsystem.
Synonym(s):
MAP2K1;MKK1;MAPKK1;PRKMK1
Purity:
≥95%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/Stability:

>6monthsat-80°C.

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Sebolt-Leopold.,J.S.,etal.NatureMed.5:810-816(1999).
2.Seger,R.,etal.FASEBJ.9:726-735(1995).
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Dual
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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