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Bpsbioscience/ZVEIDFMK/276692/10 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Bpsbioscience/ZVEIDFMK/276692/10 mg
MW:652.7Da
Formula:C31H45FN4O10
Target:Caspase6
Background:
VEIDisthespecificrecognitionsequenceforcaspase-6/Mch2.Caspase6isonlyoneofatleastthreeeffectorcaspases,theothersbeingcaspase3and7,thatareactiveduringcaspasedependentapoptosisLossofDNA-bindingactivityandTNFα-inducedapoptosiscanbepreventedbyZ-VEID-FMK.Thecaspase-6-speci?cinhibitorZ-VEID-FMKsigni?cantlypreventedapoptosisofcaspase-6-microinjectedneurons,andwasalsoabletoabolishthecleavageofprocaspase-8,althoughcaspase-6isactivateddownstreamofcaspase-8inFas-mediatedapoptosis.
Description:
Z-VEID-FMKisasyntheticpeptidethatirreversiblyinhibitsactivityofVEID-dependentcaspases(e.g.,caspase-6).Theinhibitorisdesignedasamethylestertofacilitatecellpermeability.Canbeusedforbothinvitroandinvivostudies--seenoteforusingthisproductinvitro.
Synonym(s):
Caspase-6inhibitor(fluoromethylketone);Benzyloxycarbonyl-Val-Glu(OMe)-Ile-?Asp(OMe)-fluoromethylketone
Purity:

≥90%byHPLC

BiologicalActivity:
Werecommendusing2-10µMforinhibitingcaspaseactivityincellculture.Theoptimaldosemayvaryfordifferentcellsandcultureconditions.
Solubility:
SolubleinDMSO(20mM)
Storage/Stability:

Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.

Notes:
Theinhibitorisdesignedasamethylestertofacilitatecellpermeability.Iftheintendeduseisonpurifiedorrecombinantenzymes,esteraseshouldbeaddedtogeneratefreecarboxylgroups.
AminoAcidSequence:
Z-Val-Glu(OMe)-Ile-Asp(OMe)-CH?F
ScientificCategory:
ApoptosisInhibitor
ProductType:
Inhibitor
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