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Bpsbioscience/1433 sigma Protein, Histag (Human)/79037/20 μg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Bpsbioscience/1433 sigma Protein, Histag (Human)/79037/20 μg
Species:Human
HostSpecies:Sf9insectcellsusingbaculovirus
MW:30kDa
Genbank#:NM_006142
Tag(s):N-terminalHistag
a.a:Fulllength
Background:
14-3-3sigmaorstratifinisaproteinthatisstronglyinducedbygammairradiationandotherDNA-damagingagents(1).Theinductionof14-3-3sigmaismediatedbyap53responsiveelement.Exogenousintroductionof14-3-3sigmaintocyclingcellsresultsinaG2cellcyclearrest(2).Knockoutof14-3-3sigmaincellsshowedthatthecellsareunabletomaintaincellcyclearrestafterDNAdamage.The14-3-3sigma-/-cellsdieastheyentermitosis.Thisprocessisassociatedwithafailureofthe14-3-3sigma-deficientcellstosequestertheproteinsthatinitiatemitosisandpreventthemfromenteringthenucleus.Thus,14-3-3sigmaplaysanimportantroleinmaintainingtheG2checkpointincellsandpreventingmitoticdeath.
Description:
Human14-3-3sigmaProtein,GenBankAccessionNo.NM_006142,fulllength,withN-terminalHis-tag,expressedinSf9insectcellsusingbaculovirus.MW=30kDa.
Synonym(s):
14-3-3sigma,SFN,stratifin,YWHAS
Formulation:
50mMsodiumphosphate,pH7.0,300mMNaCl,150mMimidazole,0.1mMPMSF,0.25mMDTT,25%glycerol
Storage/Stability:
Storeproductat–70°C.Foroptimalstorage,aliquottargetintosmallerquantitiesaftercentrifugationandstoreatrecommendedtemperature.Formostfavorableperformance,avoidrepeatedhandlingandmultiplefreeze/thawcycles.
Application(s):
Westernblot
Reference(s):
1.Chan,TA.etal:14-3-3-sigmaisrequiredtopreventmitoticcatastropheafterDNAdamage.Nature401:616-620,1999.

2.Hermeking,H.etal:14-3-3-sigmaisap53-regulatedinhibitorofG2/Mprogression.Molec.Cell1:3-11,1997.

ScientificCategory:
Kinase
ProductType:
Protein
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