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Bpsbioscience/PP242/27063/10 mg
MW:308.3Da
CASRegistry#:1092351-67-1
Formula:C16H16N6O
Description:
PP242isaninhibitoratthekinasedomainofthemammaliantargetofrapamycin(mTOR),whichisaSer/Thrkinaseandacellgrowthcontroller.PP242inhibitsmTORC1moreeffectivelythanrapamycin.Unlikerapamycin,PP242inhibitsbothmTORC1andmTORC2withIC50valuesof0.03and0.058µM,respectivelyanditcaninhibitcap-dependenttranslation.PP242functionsbyblockingthephosphorylationofAktatS473andpreventingmTORactivation.PP242exhitibitsIC50valuesforotherkinasesof0.11µM(JAK2),0.41µM(DNAPK),0.05µM(PKC?),0.2µM(PKCβIandII),4.4µM(EGFR),and1.5µM(VEGFR2).
Synonym(s):
Torkinib
Purity:

≥99%

Solubility:
SolubleinDMSO
Format:
Whitetooff-whitesolid
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Feldman,M.E.,etal.PLoSBiol.7:371-383(2009).
ScientificCategory:
Kinase
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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