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Bpsbioscience/AMPK (A2/B2/G1), Histag/40705/5 µg
Species:Human
HostSpecies:Sf9insectcells
MW:~146kDa(complex)
Genbank#:NM_006252(A2),NM_005399(B2),NM_002733(G1)
Tag(s):C-terminalHis-tag
a.a:fulllength
Background:
AMP-activatedproteinkinase(AMPK)exhibitsakeyroleasamasterregulatorofcellularenergyhomeostasis(1).AMPKexistsasaheterotrimericcomplexcomposedofacatalyticαsubunitandregulatoryβandγsubunits.BindingofAMPtotheγsubunitallostericallyactivatesthecomplex.AMPKisactivatedinresponsetostressesthatdepletecellularATP(lowglucose,hypoxiaandischemia)andviasignalingpathwaysinresponsetoadiponectin,leptinandCAMKKβ(2).
Description:
RecombinanthumanAMPK(combinationofA2/B2/G1subunits),fulllength,withC-terminalHis-tags,expressedinSf9insectcellsviaabaculovirusexpressionsystem.MW=69kDa(A2),36kDa(B2),41kDa(G1).
Synonym(s):
SubunitA2:PRKAA2,AMPK,AMPK2,PRKAA
SubunitB2:PRKAB2,MGC61468
SubunitG1:PRKAG1,AMPKG,MGC8666
Purity:
≥75%
Formulation:
50mMsodiumphosphate,pH7.0,300mMNaCl,150mMimidazole,0.1mMPMSF,0.25mMDTT,25%glycerol.
Format:
Aqueousbuffersolution
Storage/Stability:

>6monthsat-80°C.

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Hardie,G.D.TheAMP-activatedproteinkinasepathway–newplayersupstreamanddownstream.J.CellSci.2004;117:5479–5487.
2.Kahn,B.B.etal.AMP-activatedproteinkinase:Ancientenergygaugeprovidescluestomodernunderstandingofmetabolism.CellMetab;2005:1,15–25.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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