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Bpsbioscience/SENP1 Core Domain, Histag/81092/25 µg
Species:Human
HostSpecies:E.coli
MW:28kDa
Tag(s):His-tag
Background:
SENP1isaSUMOisopeptidasethatplaysacriticalroleinthedevelopmentofprostatecancer.SENP1isoverexpressedinprostatecancersamplesandtransgenicoverexpressionofSENP1intheprostateofmiceleadstothedevelopmentofprostaticintraepithelialneoplasiaatanearlyage.Consistentwiththemodelstatedabove,investigatorshavedemonstratedthatoverexpressionofSENP1enhancesandrogen-receptormediatedtranscription.InactivationofSENP1inmicebyretroviralinsertionalmutationisembryoniclethal(e12.5-e14.5)andleadstoanincreaseinthesteady-statelevelsofSUMOylatedformsofanumberofproteins.DepletionofSENP1levelsinPC3cellsbyRNAileadstoadecreaseincyclinD1expression.TransgenicoverexpressionofSENP1intheprostateofmiceleadstoneoplasiaatanearlyage.AlloftheseexperimentsdemonstratethatSENP1playsacrucialroleinthegrowthanddevelopmentoforganisms.ReinforcingthepotentialroleSENP1mayplayinprostatecanceristheobservationthatSENP1isoverexpressedinmanyprostatecancersamples.
Description:
HumanSENP1CoreDomainrecombinantprotein,withHis-tag,expressedinE.coli.
UniProt
Q9P0U3
Synonym(s):
Sentrin/SUMO-specificproteaseSENP1,Sentrin-specificprotease1,SMT3specificpeptidase1
Format:
Aqueousbuffersolution
Storage/Stability:

Storeatorbelow–80°C.Stableassuppliedforupto1yearwhenstoreddessicatedat–80°C.

Application(s):
ThisenzymeisactiveintheSUMO3-CHOPassay.
Reference(s):
1.Cheng,J.,etal.,Roleofdesumoylationinthedevelopmentofprostatecancer.Neoplasia,2006.8(8):p.667-76.
2.Cheng,J.,etal.,SENP1enhancesandrogenreceptor-dependenttranscriptionthroughdesumoylationofhistonedeacetylase1.MolCellBiol,2004.24(13):p.6021-6028.
3.Yamaguchi,T.,etal.,MutationofSENP1/SuPr-2revealsanessentialrolefordesumoylationinmousedevelopment.MolCellBiol,2005.25(12):p.5171-82.
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Ubiquitination(SUMOylation)
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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