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Bpsbioscience/Celastrol/277022/50 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Bpsbioscience/Celastrol/277022/50 mg
MW:450.6Da
CASRegistry#:34157-83-0
Formula:C29H38O4
Description:
Celastrolisanaturallyoccurringtriterpenoidantioxidantcompoundwithanti-inflammatoryactivity.InhibitsNFkappaB(IC50=270nM).Itinducesheatshockresponseandcytoprotectioninvariouscells.Celastrolinhibits20Sproteasomechymotrypsin-likeactivity(IC50=2.5μM).Cellpermeable.
Synonym(s):
Tripterine
Purity:
>98%byTLC.
Solubility:
SolubleinDMSO(45mg/ml)orEthanol(30mg/ml)
Format:
Redpowder
Storage/Stability:

Storeat+4°C.Stableassuppliedforupto2yearswhenstoreddessicatedat+4°C.Storesolutionsat-20°Cforupto1month.

Application(s):
UsefulforinhibitionofNF-kappa-B-dependentpathwaysandinhibitionof20Sproteasomechymotrypsin-likeactivity.
Reference(s):
1.Sethi,G.,etal.Celastrol,anoveltriterpene,potentiatesTNF-inducedapoptosisandsuppressesinvasionoftumorcellsbyinhibitingNF-kappaB-regulatedgeneproductsandTAK1-mediatedNF-kappaBactivation.Blood,2007,109:2727.
2.Westerheide,S.D.etal.Celastrolsasinducersoftheheatshockresponseandcytoprotection.J.Biol.Chem.2004.279:56053.
3.Kiaei,M.,etal.Celastrolblocksneuronalcelldeathandextendslifeintransgenicmousemodelofamyotrophiclateralsclerosis.Neurodegener.Dis.2005,2:246.
Warning(s):
Protectfromlight.Protectfrommoisture.Avoidfreeze/thawcycles.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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