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Bpsbioscience/Cyclopamine, Free Base/27013/10 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Bpsbioscience/Cyclopamine, Free Base/27013/10 mg
MW:411.6Da
CASRegistry#:4449-51-8.
Formula:C27H41NO2
Description:
CyclopamineinhibitsactivationoftheHedgehogresponsepathwaybybindingtoandinhibitingtheproto-oncogeneSmoothened(SMO).TheeffectsofoncogenicmutationsthateitheractivateSMOorinactivatethetumorsuppressorPatched(Ptch)canbereversedbycyclopaminetreatment.Cyclopaminehasalsobeenshowntoinduceapoptosisincolorectaladenomacelllines,carcinoma-derivedcelllines,andskinbasalcellcarcinomasandisbeinginvestigatedasananti-cancerdrug.
Purity:

≥99%byHPLC

BiologicalActivity:
CyclopamineinhibitstheactivityforHedgehogsignaling-dependentmotorneurondifferentiationwithIC50=300nmol/L.
Solubility:
Solubleinethanol,methanolandDMSO.Ethanolisthebestsolventforbiologicaluse.Tomakea2%solution,heatcyclopamineinethanolto50-60°C.InmethanolorDMSO,solubilityis7mg/mland4mg/mlrespectively.
Format:
Whitetooff-whitecrystallinesolid
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Taipale,J.,etal.,Nature2000;406:944–945.
2.Chen,J.K.,etal.,Genes&Dev.2002;16:2743–2748.
3.Qualtrough,D.,etal.,IntJCancer.2004;110:831-837.
ScientificCategory:
HedgehogPathway
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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