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Bpsbioscience/Mouse AURORA A, GSTtag/40177/10 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Bpsbioscience/Mouse AURORA A, GSTtag/40177/10 µg
Species:Mouse
HostSpecies:Sf9insectcells
MW:72kDa
Genbank#:NM_011497
Tag(s):N-terminalGST-tag
a.a:fulllength
Background:
AURORAAbelongstoamultigenicfamilyofmitoticserine/threoninekinaseswhichareinvolvedinthecontrolofchromosomesegregation.AURORAAisinvolvedincentrosomeseparation,duplicationandmaturationaswellasinbipolarspindleassemblyandstability(1).AURORAAisexpressedandactiveatthehighestlevelduringG2-Mphaseofthecellcycle.OverexpressionofAURORAAhasbeenfoundtobecorrelatedwiththegradeofvarioushumansolidtumours.EctopicAURORAAoverexpressioninanyculturecelllineleadstopolyploidyandcentrosomeamplification(2).
Description:
RecombinantmouseAURORAA,fulllength,withN-terminalGST-tag,expressedinSf9insectcellsviaabaculovirusexpressionsystem.
Synonym(s):
IAK;Ark1;Ayk1;STK6;AIRK1;AU019385;AW539821;STK15;AURKA;AIK;AURA;BTAK;AURORA2
Purity:
≥90%
Formulation:
50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
Format:
Aqueousbuffersolution
Storage/Stability:

>6monthsat-80°C.

Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Dutertre,S.etal:Ontheroleofaurora-Aincentrosomefunction.Oncogene.2002Sep9;21(40):6175-83.
2.Katayama,H.etal:TheAurorakinases:roleincelltransformationandtumorigenesis.CancerMetastasisRev.2003Dec;22(4):451-64.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.

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