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Bpsbioscience/IBET762/276301/5 mg
MW:423.9Da
CASRegistry#:1260907-17-2
Formula:C22H22ClN5O2
Target:BET
Background:
Bromodomainshaveanimportantroleinthetargetingofchromatin-modifyingenzymestospecificsites,includingmethyltransferases,HATsandtranscriptionfactorsandregulatediversebiologicalprocessesfromcellproliferationanddifferentiationtoenergyhomeostasisandneurologicalprocesses.
Description:
I-BET-762isasmallmoleculeinhibitoroftheBETfamilyofbromodomaincontainingproteins.IthasbeenshowntobindtotheacetylatedlysinerecognitionmotifsonthebromodomainofBETproteins.ThisbindingpreventstheinteractionofbetweenBETproteinsandacetylatedhistonepeptides.
Synonym(s):
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Solubility:
SolubleinWater
Storage/Stability:
Powderisstableat-20°Cforupto3years.Re-suspendedpowderisstableat-80°Cforupto6months.
Reference(s):
NicodemeE,etal.Nature.2010Dec23;468(7327):1119-23.
ScientificCategory:
BromodomainInhibitor
ProductType:
Inhibitor
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