Everest Biotech/Erlotinib HCl 2g/1100150023/2g

Molecular Weight:	429.9 g/mol
Molecular Formula:	C22H23N3O4•HCl
CAS Number :	183319-69-9
Solubility:	Soluble in DMSO at 18 mg/mL with warming; very poorly soluble in ethanol
Purity:	≥99%
Storage:	-20C
Applications:	Anti-neoplastic

Material Safety Data Sheet

Date:Oct 23,2015

1. PRODUCT AND COMPANY IDENTIFICATION

1.1 Product identifier

Product name: Erlotinib HCl

Catalog No:1100150013,1100150023,1100150053,1100150103,1100150253

1.2 Relevant identified uses of the substance or mixture and uses advised against

For research use only.

1.3 Details of the supplier of the safety data sheet

Company:Eton Bioscience Inc

TollFree:1-800-758-1630

Tel:1-800-758-1630

Fax:1-800-507-2912

1.4 Emergency telephone number

1-800-758-1630

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture

Acute toxicity: oral, Category 4

Acute toxicity:dermal,Categort 4

Acute toxicity:inhalation(Dusts/Mists),Category 4

Skin corrosion/irritation,Category 2

Serious eye damage/eye irritation,Category 2A

Specific target organ toxicity, Category 3

2.2 GHS Label elements, including precautionary statements

Pictogram

2.3 Other hazards

None

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Molecular Formula:C₂₉H₃₁N₇O.CH₄SO₃

Molecular Weight:429.9g/mol

CAS No:183319-69-9

4. FIRST AID MEASURES

4.1 Description of first aid measures

Eye contact

Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician

Skin Contact

Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician

Inhalation

If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration

Ingestion

If swallowed, wash out mouth with copious amounts of water; call a physician

4.2 Most important symptoms and effects, both acute and delayed

No information available

4.3 Indication of any immediate medical attention and special treatment needed.

No information available

5. FIRE FIGHTING MEASURES

5.1 Extinguishing media

Suitable extinguishing media

Water spray, carbon dioxide, dry chemical powder or foam

5.2 Special hazards arising from the substance or mixture

No information available

5.3 Advice for firefighters

Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions,protective equipment and emergency procedures

Use full personal protective equipment. Evacuate personnel to safe areas.

6.2 Environmental precautions

Prevent further leakage or spillage. Prevent product from entering drain.

6.3 Methods and material for containment and cleaning up

Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE

7.1 Precautions for safe handling

Avoid skin/eye contact. Use protective equipment as needed. Wash contaminated clothing before reuse.

7.2 Conditions for safe storage,including any incompatibilities

Keep container tightly closed in a cool,well-vented place. Store at -20˚C.

7.3 Specific end use(s)

No data available.

8. EXPOSURE CONTROLS/PERSONAL INFORMATION

8.1 Control Parameters

This product contains no hazardous materials with occupational exposure limits.

8.2 Exposure controls

Engineering controls

Provide shower and eye wash station

Personal protective equipment

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

9.2 Other safety information

No data available.

10. STABILITY AND REACTIVITY

10.1Reactivity

No data available

10.2Chemical stability

Stable under recommended storage conditions.

10.3Possibility of hazardous reactions

No data available.

10.4Conditions to avoid

Protect from light and heat

10.5Incompatible materials

strong oxidizing agents

10.6Hazardous decomposition products

Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION

11.1Information on toxicological effects

Toxicological effects on this product have not been thoroughly studied.

12. ECOLOGICAL INFORMATION

12.1Toxicity

Avoid release into environment

12.2Persistence and degradability

No data available

12.3.Bioaccumulative potential

No data available

12.4Mobility in soil

No data available

12.5Results of PBT and vPvB assessment

No data available

12.6Other adverse effects

No data available

13. DISPOSAL INFORMATION

13.1Waste treatment methods

Dispose in accordance with local, state, and federal regulations.

14. TRANSPORT INFORMATION

DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

IMDG:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATORY INFORMATION

EU Risk and Safety phrases:

R22: Harmful if swallowed

S22: Do not breathe dust

S24/25: Avoid contact with skin and eyes

S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

S28:after contact with skin, wash immediately with plenty of water

S36/37/39:Wear suitable protective clothing,gloves and eye/face protection

16. OTHER INFORMATION

Wang Y, Yuan JL, Zhang YT, Ma JJ, Xu P, et al. (2013) Inhibition of Both EGFR and IGF1R Sensitized Prostate Cancer Cells to Radiation by Synergistic Suppression of DNA Homologous Recombination Repair. PLoS ONE 8(8): e68784. doi:10.1371/journal.pone.0068784