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| Molecular Formula: | C44H69NO12 H2O |
| Molecular Weight: | 822.03 g/mol |
| CAS Number: | 109581-93-3 |
| Solubility: | Soluble in DMSO or100% ethanol, methanol, ethyl acetate or acetone: insoluble in water. |
| Purity: | ≥98% |
| Storage: | -20ºC |
| Applications: | Immunosupressive properties very similar to cyclosporine, but ten to a hundred times more potent |
Material Safety Data Sheet
Date:Oct 21,2015
1. PRODUCT AND COMPANY IDENTIFICATION
1.1 Product identifier
Product name: FK-506
Catalog No:1100060012,1100060052,1100060102
1.2 Relevant identified uses of the substance or mixture and uses advised against
For research use only.
1.3 Details of the supplier of the safety data sheet
Company:Eton Bioscience Inc
TollFree:1-800-758-1630
Tel:1-800-758-1630
Fax:1-800-507-2912
1.4 Emergency telephone number
1-800-758-1630
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
Acute Toxicity-Oral,Category 3
2.2 GHS Label elements, including precautionary statements
Pictogram
| Signal Word | Danger |
| Hazard Statement |
|
| H301 | Toxic if swallowed |
| Precautionary statement |
|
| P264 | Wash skin thoroughly after handling |
| P302+P310 | IF SWALLOED: immediately call a POISON CENTER or doctor/physician |
| P330 | Rinse mouth |
| P501 | Dispose of contents/container to an approved waste disposal plant |
2.3 Other hazards
None
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
Molecular Formula: C44H69NO12 H2O
Molecular Weight:822.03g/mol
CAS No:109581-93-3
4. FIRST AID MEASURES
4.1 Description of first aid measures
Eye contact
Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
Skin Contact
Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
Inhalation
If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
Ingestion
If swallowed, wash out mouth with copious amounts of water; call a physician
4.2 Most important symptoms and effects, both acute and delayed
No information available
4.3 Indication of any immediate medical attention and special treatment needed.
No information available
5. FIRE FIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media
Water spray, carbon dioxide, dry chemical powder or foam
5.2 Special hazards arising from the substance or mixture
No information available
5.3 Advice for firefighters
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions,protective equipment and emergency procedures
Use full personal protective equipment. Evacuate personnel to safe areas.
6.2 Environmental precautions
Prevent further leakage or spillage. Prevent product from entering drain.
6.3 Methods and material for containment and cleaning up
Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Avoid skin/eye contact. Use protective equipment as needed. Wash contaminated clothing before reuse.
7.2 Conditions for safe storage,including any incompatibilities
Keep container tightly closed in a cool,well-vented place. Store at -20˚C.
7.3 Specific end use(s)
No data available.
8. EXPOSURE CONTROLS/PERSONAL INFORMATION
8.1 Control Parameters
This product contains no hazardous materials with occupational exposure limits.
8.2 Exposure controls
Engineering controls
Provide shower and eye wash station
Personal protective equipment
| Eye Protection | Wear safety goggles |
| Skin Protection | Wear protective clothing |
| Hand Protection | Wear protective gloves |
| Respiratory protection | Wear NIOSH/MSHA approved respirators |
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
| Appearance | Solid |
| pH | No data available |
| Melting point | No data available |
| Freezing point | No data available |
| Boiling point | No data available |
| Density | No data available |
| Water solubility | Insoluble |
9.2 Other safety information
No data available.
10. STABILITY AND REACTIVITY
10.1Reactivity
No data available
10.2Chemical stability
Stable under recommended storage conditions.
10.3Possibility of hazardous reactions
No data available.
10.4Conditions to avoid
Protect from light and heat
10.5Incompatible materials
Strong oxidizing agents
10.6Hazardous decomposition products
Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
11. TOXICOLOGICAL INFORMATION
11.1Information on toxicological effects
Toxicological effects on this product have not been thoroughly studied.
12. ECOLOGICAL INFORMATION
12.1Toxicity
Avoid release into environment
12.2Persistence and degradability
No data available
12.3.Bioaccumulative potential
No data available
12.4Mobility in soil
No data available
12.5Results of PBT and vPvB assessment
No data available
12.6Other adverse effects
No data available
13. DISPOSAL INFORMATION
13.1Waste treatment methods
Dispose in accordance with local, state, and federal regulations.
14. TRANSPORT INFORMATION
DOT:
UN number:2811 Class:6.1,Packing group:III
Proper shipping name: Toxic solids,organic,n.o.s(FK506)
Marin pollutant:No
Poison Inhalation Hazard:No
IATA:
UN number:2811 Class:6.1,Packing group:III
Proper shipping name: Toxic solids, organic, n.o.s(FK506)
IMDG
UN number:2811 Class:6.1,Packing group:III
EMS-No:F-A,S-A
Proper shipping name: TOXIC SOLID, ORGANIC,N.O.S(FK506)
Marine pollutant:No
15. REGULATORY INFORMATION
EU Risk and Safety phrases:
R25: Toxic if swallowed
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37/39:Wear suitable protective clothing,gloves and eye/face protection
16. OTHER INFORMATION
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information. Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.
John H. Boyd, Maziar Divangahi, Linda Yahiaoui, Dusanka Gvozdic, Salman Qureshi, and Basil J. Petrof. MOLECULAR PATHOGENESIS:Toll-Like Receptors Differentially Regulate CC and CXC Chemokines in Skeletal Muscle via NF-kappa B and Calcineurin Infect. Immun.,Dec 2006; 74: 6829 - 6838.