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Neuromics/PGP9.5/RA12103/150 ul

Type:RabbitIgG

 

Applications:IHC;WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;P;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:Wholeserum-liquid

 

Immunogen:ASSEDTLLKDAAKVCR

 

Image of PGP9.5 176-191, Protein Gene Product 9.5, Ubiquitin C-terminal hydrolase 1, UCHL1 or Park5 Antibody

PGP9.5isasolublecytoplasmicproteinwithamolecularweightofapproximately25,000kD.Itispresentinneuronsandincellsofthediffuseneuroendocrinesystem.PGP9.5functionsasatissue-specificubiquitincarboxylterminalhydrolaseisoenzyme.ThisenzymeisalsoknownasUCH-L1.Becauseofitsabundanceinnerves,ithasbeenwidelyusedasaMarkerforperipheralnervefibers.

It wasalsodiscoveredasagenemutatedinsomerarefamialformsofParkinsonsdisease.InterestinglyacommonallelicvariantofUCHL1,theS18YpolymorphismisactuallyprotectiveagainstParkinsonsdisease.Itisalsoamarkerfor cellsofthediffuseneuroendocrinesystemandtheirtumors.

PGP9.5176-191CustomerPublications


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