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Neuromics/BMP-4/PR27024-2/2 ug

Type:Protein

 

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Picture
Theproteinencodedbythisgeneisamemberofthebonemorphogeneticproteinfamilywhichispartofthetransforminggrowthfactor-betasuperfamily.Thesuperfamilyincludeslargefamiliesofgrowthanddifferentiationfactors.BonemorphogeneticproteinswereoriginallyidentifiedbyanABIlityofdemineralizedboneextracttoinduceendochondralosteogenesisinvivoinanextraskeletalsite.Thisparticularfamilymemberplaysanimportantroleintheonsetofendochondralboneformationinhumans,andareductioninexpressionhasbeenassociatedwithavarietyofbonediseases,includingtheheritabledisorderFibrodysplasiaOssificansProgressiva.Alternativesplicinginthe5"untranslatedregionofthisgenehasbeendescribedandthreevariantsaredescribed,allencodinganidenticalprotein. 

Image: BMP-4proteinstructureandsequence

References:

1.Effectsofbonemorphogeneticprotein4ondifferentiationofembryonicstemcellsintomyosinVIIa-positivecells. ActaOtolaryngolSuppl2007Feb;(557):36-40
2.Promotinglumbarspinalfusionbyadenovirus-mediatedbonemorphogeneticprotein-4genetherapy. ChinJTraumatol2007Apr;10(2):72-6
3.TNF-alpharepressestranscriptionofhumanBoneMorphogeneticProtein-4inlungepithelialcells. Gene2007May15;393(1-2):70-80
4.Aroleforbonemorphogeneticprotein-4inADIpocytedevelopment. CellCycle2007Feb1;6(4):385-9
5.Regulatingtheroleofbonemorphogeneticprotein4intoothbioengineering. JOralMaxillofacSurg2007Mar;65(3):501-7
6.Bonemorphogeneticprotein-4isoverexpressedincolonicadenocarcinomasandpromotesmigrationandinvasionofHCT116cells. ExpCellRes2007Mar10;313(5):1033-44

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