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Neuromics/Cathepsin S/GT15198/100 ug

Type:GoatIgG

 

Applications:IHC;WB;IP;E

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:NS0-derived,recombinantCathepsinS(rhCathepsinS;aa17-331).

 

Picture

CathepsinSisalysosomalcysteineproteaseofthepapainfamily.HumanCathepsinSissynthesizedasapreproenzymeof331aminoacidresiduesconsistingasignalpeptide(residues1-16),aproregion(residues17-114),andthematureenzyme(residues115-331).

Image:CathepsinSstainingofimmersionfixedparaffin-embeddedsectionsofhumanlymphnode(15µg/mLovernightat4°C).TissuewasstainedusingtheAnti-GoatHRP-DAB(brown)andcounterstainedwithhematoxylin(blue).

CathepsinS isexpressedinhumanadiposetissueandcertaintumors.IthasalsobeenshowntobeabletofunctionasanelastaseoverabroadpHrangeinalveolarmacrophages.Transcriptvariantsutilizingalternativepolyadenylationsignalsexistforthisgene.


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