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Neuromics/CCK8 (Cholecystokinin Octapeptide)/RA20078/100 ul188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Neuromics/CCK8 (Cholecystokinin Octapeptide)/RA20078/100 ul

Type:RabbitIgG

 

Applications:IF;IHC

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:Wholeserum-liquid

 

Immunogen:SulfatedCCK-8(26-33)coupledtobovinethyroglobulin(BTg)withglutaraldehyde.

 

Picture

Cholecystokinin(CCK)isoneofthemostimportanthormoneregulatorsofthedigestiveprocess.Thepeptideisconcentratedintheproximalsmallintestine(CCKcells)andissecretedintothebloodinresponsetotheingestionofproteinsandfats,whereitsactionsincludethestimulationofpancreaticsecretion,themodulationofinsulinoutput,theregulationofgastricemptying,andgallbladdercontraction.InthecentralnervoussystemCCKergicfibresarewidespread,beingparticularlyabundantinthecerebralcortex.Insomemesolimbicneuronsprojectingtothenucleusaccumbens,CCKiscolocalisedwithdopamineandithasbeensuggestedthatCCKmightfacilitatethefunctionofdopamineineventssuchasstimulusrewardassociativebehaviour.SecretionofCCKfromthemurinetumourcelllineSTC1hasbeenshowntobestimulatedbypituitaryadenylatecyclaseactivatingprotein(PACAP)andhasraisedthepossibilitythatPACAPmayfunctionasaneuromodulatorofCCKreleasefromgutendocrinecellsinvivo.CCK-8isalsosuspectedtoheightenpainsensationindiabetics.

 Image:Cholecystokinin8terminalsandfibersinratdorsalhorn(spinalcord),vibratomesections,ABCdetection.


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