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Neuromics/Semaphorin 5A/GT41026/100 ug

Type:GoatIgG

 

Applications:IHC

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:PeptidewithsequenceDEATKKACYSKGKS(correspondingtoapartoftheextra-cellulardomain)fromtheinternalregionoftheproteinsequenceaccordingtoNP_003957.1.

 

Picture

Membersofthesemaphorinproteinfamilyareinvolvedinaxonalguidanceduringneuraldevelopment.Semaphorin5aisthoughttohaveabifunctionalroleinaxonguidance,exertingbothattractiveandinhibitoryeffectsondevelopingaxonsassociatedwithlimbicfunction.ThethrombospondinrepeatsofSemaphorin5aphysicallyinteractwithbothheparansulfateproteoglycansandchondroitinsulfateproteoglycans,inducingattractiveandinhibitoryguidancecues,respectively.TheBIOLOGicalresponsestoSemaphorin5aareinducedthroughbindingtoitshigh-affinityreceptor,plexinB3,triggeringintracellularsignalingthroughMe

Image: Semaphorin5a (dilution:2.5µg/ml)stainingofparaffinembeddedHumanKidney.SteamedantigenretrievalwithcitratebufferpH6,AP-stainingProtocolonData-sheet.

Semaphorine5Aplaysaroleinautism,reducingtheABIlityofneuronstoformconnectionswithotherneuronsincertainbrainregions

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