
EMAP-IIisatumorderivedcytokinethatplaysaroleinawidevarietyofactivitiesonendothelialcells,monocytesandneutrophils.EMAP-IIinhibitsendothelialcellproliferation,vasculogenesis,neovesselformation,andcaninduceapoptosis.Itisalsochemotactictowardsneutrophilsandmonocytesandinducesmyeloperoxidaseactivityfromneutrophils.EMAP-IIclinicalvalueisinhibitingangiogenesisofvascularbedsandsuppressingthegrowthofprimaryandsecondarytumorswithnoaffecttonormaltissues.