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Neuromics/BACE1/MO15066/100 ug

Type:MouseIgG

 

Applications:E;IHC;IP;WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:ProteinGPurified-liquid

 

Immunogen:NS0-derivedrhBACE-1ectodomain

 

Picture

Cleavageofamyloidprecursorprotein(APP)into40or42aminoacidamyloidβ(aβ)peptidesisaresultoftheactionoftwoproteasesβ-andγ-secretase.Thebeta-siteAPPcleavingenzyme,orBACE-1,isatransmembraneasparticproteasethatislocalizedinthegolgiandendosomes.LowlevelsofBACE-1mRNAarefoundinmostadulttissueswithahigherlevelofexpressioninpancreas.

ItisimportantinthepathogenesisofAlzheimersdisease,andintheformationofmyelinsheathsinperipheralnervecells. 

Image:DetectionofBACE-1inhumancerebellum.StainedwithHRP-DAP(brown)andcounter-stainedwithhemtoxylin(blue). 


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