CART(CocaineandAmphetamine-regulatedTranscript)propeptide(aminoacids(aa)28-116)isasecretedproteinthatisprocessedbyProhormoneConvertases1/3and2togenerate4kDato5kDabioactivepeptidesthatactasneurotransmittersandneuroendocrinefactors.HumanProCARTsharesmorethan95%aaidentitytoratandmousecounterparts.CARTiswidelyexpressedinthecentralnervoussystemandplaysimportantrolesinvariousphysiologicalprocessesincludingregulatingsatiety,foodintake,andweightregulation.CARTexpressionisnotregulatedbycocaine.