
HumanGFAPisa49,749daltonprotein(432aminoacids)expressedinastrocytes.GFAPisanintermediatefilamentproteinandactsasanintracellularstructuralcomponentofthecytoskeleton.Duringembryonicandfetallife,GFAPisalsoexpressedbyradialglialcellsoftheCNS.VariousmutationsoftheGFAPgeneinhumansproduceAlexandersdisease,oneoftheleukodystrophies.
Image:Atissuesectionthroughane18mousebrainshowingGFAP(brown)stainingofradialglialcells(a.k.a.Bergmanfiberofthecerebellum).
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