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Neuromics/GM CSF Mouse/PR270742/2 ug

Type:Protein

 

SpeciesReactivity:M

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Picture
GMCSFisacytokinethatcontrolstheproduction,differentiation,andfunctionofgranulocytesandmacrophages.Theactiveformoftheproteinisfoundextracellularlyasahomodimer.Thisgenehasbeenlocalizedtoaclusterofrelatedgenesatchromosomeregion5q31,whichisknowntobeassociatedwithinterstitialdeletionsinthe5q-syndromeandacutemyelogenousleukemia.Othergenesintheclusterincludethoseencodinginterleukins4,5,and13.
GM-CSFstimulatesthegrowthanddifferentiationofhematopoieticprecursorcellsfromvariouslineages,includinggranulocytes,macrophages,eosinophilsanderythrocytes.

Image: GM-CSF MouseStructureandSequence.

References:

1.Granulocyte-macrophagecolonystimulatingfactorandinterleukin-8inthereproductivetractofewesfollowingoestrusandmating ReprodFertilDev2007;19(4):585-93.

2.Useofgranulocyte-macrophagecolony-stimulatingfactortoreverseanergyinotherwiseimmunologicallyhealthychildren.AnnAllergyAsthmaImmunol2007Apr;98(4):373-82.

3.[Plasmagranulocyte-macrophagecolonystimulatingfactor(GM-CSF)andactivityofenzymesingranulocytesofbreastcancerpatients]PrzeglLek2006;63(8):654-7.

4.Granulocyte-macrophagecolony-stimulatingfactor(CSF)andmacrophageCSF-dependentmacrophagephenotypesdisplaydifferencesincytokineprofilesandtranscriptionfactoractivities:implicationsforCSFblockadeininflammation.JImmunol2007Apr15;178(8):5245-52.

5.Granulocytecolony-stimulatingfactorandgranulocytemacrophagecolony-stimulatingfactorexacerbateatherosclerosisinapolipoproteinE-deficientmice. Circulation2007Apr17;115(15):2049-54.

6.Re:Clinicalandimmunologicalcharacteristicsofpatientswithserologicprogressionofprostatecancerachievinglong-termdiseasecontrolwithgranulocyte-macrophagecolony-stimulatingfactor:B.I.Rini,L.Fong,v.Weinberg,B.KavanaughandE.J.Small.JUrol2006;175:2087-2091. JUrol2007Apr;177(4):1585;authorreply1585-6. 


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