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Neuromics/CD39/GP10103/150 ul

Type:GuineaPigIgG

 

Applications:IHC

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:Wholeserum-liquid

 

Immunogen:DAGSSHTNLYIY

 

Picture

HumanCD39isfoundonmostmatureBcells,activatedNKcellsandactivatedTcells.CD39isalsoweaklyexpressedongranulocytes.CD39hashomologytotheNmycfamilyofproteinsandwasrecentlycloned.CD39canhydrolyzebothnucleosidetriphosphatesanddiphosphates.CD39isthedominantectonucleotidaseofvascularandplacentaltrophoblastictissuesandappearstomodulatethefunctionalexpressionoftype2purinergic(P2)Gproteincoupledreceptors(GPCRs).CD39transgenicmiceexhibitimpairedplateletaggregation,prolongedbleedingtimes,andresistancetosystemicthromboembolism.ThereisacorrelationbetweenATPhydrolysisandtriglyceridesinpatientswithchronicheartdisease,suggestingarelationshipbetweenATPdiphosphohydrolaseandthrombogenesis

CD39couldouldalsoplayaintype2Diabetes.

Image:CD39distributioninratpancreaticducts.JPhysiol(2003),551.3,pp.881-892©Copyright2003ThePhysiologicalSociety.DOI:10.1113/jphysiol.2003.049411

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