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Neuromics/GluR4/AMPA4/P41012/100 ug Blocking Peptide188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Neuromics/GluR4/AMPA4/P41012/100 ug Blocking Peptide

Type:GoatIgG

 

Applications:IHC;WB;E

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:B;H;M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:Syntheticpeptide:C-KKLDQREYPGSETP,fromtheinternalregionoftheproteinsequenceaccordingtoNP_000820.3;NP_001070711.1;NP_001070712.1.

 

Picture

Humanglutamatereceptor4(GRIA4)isanewmemberofthefamilyofionotropicglutamatereceptorswhicharethepredominantexcitatoryneurotransmitterreceptorsinthemammalianbrain.BindingstudiesshowedthathumanGluR4transfectedintosimiankidneycells(COS-1)exhibitshighspecificbindingfor[3H](RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionicacid([3H]AMPA)butnot[3H]kainate.IonsubstitutionexperimentsindicatethathGluR4receptor-linkedionchannelsintheirhomomericstatearepermeabletobothCA2+andNa+ions.ImmunoprecipitationstudiessuggestthatGRIA1existsinsituintheformofapentamer.

Image:GluR4stainingofhumanbraintissue,cortex(formalin-fixedparaffin-embedded)at5ug/mlfollowedbybiotinylated horseanti-goatIgGsecondaryantibody, alkalinephosphatase-streptavidinandchromogen.Protocolondata-sheet.

Nociceptors,involvedprimarilyinthemediationofneuropathicpain,maybepresynapticallymodulatedbyGluR4-containingAMPAreceptors.


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