
TheSOX(SRY-boxcontaininggene)genefamilyencodesagroupoftranscriptionfactorsdefinedbytheconservedhighmotilitygroup(HMG)DNA-bindingdomain.Theyareinvolvedintheregulationofembryonicdevelopmentandinthedeterminationofcellfate.
SOX2belongstotheSOX(SRY-likeHMGbox)familyoftranscriptionfactorswithdiverserolesindevelopment.SOX2functionsinspecifyingthefirstthreelineagespresentatimplantationandinregulatingproliferationanddifferentiationinthedevelopingperipheralnervoussystem.1-5
Image:SOX2stainingofhumanNTERA-2cells.CellswerestainedusingRhodamineRed-conjugateddonkeyanti-MouseIgGsecondaryantibody.
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