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Neuromics/Prion Protein/CD230/CH23027/200 ul

Type:ChickenIgY

 

Applications:ICC

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:RecombinantfragmentoftheHumanPrion

 

Picture

PrionproteinistheproteinresponsibleforhumanCreutzfeldt-JakobDisease(CJD),andsomaticmutationsofthepriongeneareresponsibleforGerstmann-Straussler-ScheinkerdiseaseandFatalFamilialInsomnia.ThebovinehomologoftheprionproteinisresponsibleforbovineSpongioformEncephalopathy(BSE),alsoknownas“MadCowDisease.”Inallcases,theprionproteinhastwofoldingstates,withonestatebeingthe“normal”non-pathologicalform,andtheotherstateinducingaspongioformencephalopathy.

Normalprionproteinsproducednaturallyinthebraininteractwiththeamyloid-βpeptidesthatarehallmarksofAlzheimersdisease.Blockingthisinteractioninpreparationsmadefrommousebrainshaltedsomeneurologicaldefectscausedbytheaccumulationofamyloid-βpeptide.Itwaspreviouslythoughtthatonlyinfectiousprionproteins,ratherthantheirnormal,non-infectiouscounterparts,playedaroleinbraindegeneration(Nature,doi:10.1038/news.2009.121).

Image:PrionProteinstainingofculturedfibroblastscellstransientlytransfectedwithaplasmidcontainingtheprionproteincDNA.


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