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Neuromics/alpha Synuclein/MO15053/500 ug

Type:MouseIgG

 

Applications:WB;E

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:ProteinGPurified-liquid

 

Immunogen:RecombinanthumanalphaSynuclein

 

alphaSynucleinisamemberofafamilyofsmall,highlyconservedproteins,includingsynuclein-alpha,-beta,and-gamma,andsynoretin.Theseproteinsarelocalizedpredominantlyinthebrain,concentratedinpresynapticnerveterminals.Synuclein-alphaisnormallyasolubleprotein.Abnormalsynuclein-alphaformsfilamentousinclusions(LewybodiesandLewyneurites)inseveralneurodegenerativediseases,includingParkinsonsdisease(PD),dementiawithLewybodies,andAlzheimersdisease.ItisamajorcomponentofintracellularinclusionsinsporadicPD.Mutationsinthesynuclein-alphagene(A53TandA30P)havebeenreportedinseveralfamilieswithautosomaldominantParkinsonism.


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