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Neuromics/PSD95/SAP90/MO50000/100 ul

Type:MouseIgG

 

Applications:IF;IHC;IP;WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:Fusionproteinaminoacids77-299ofhumanPSD-95/SAP90(accessionnumberP78352).

 

Picture

PSD-95orSAP90isthebeststudiedmemberoftheMAGUK-familyofPDZdomain-containingproteins.LikeallMAGUK-familyproteins,itsbasicstructureincludesthreePDZdomains,anSH3domain,andaguanylatekinase-likedomain(GK)connectedbydisorderedlinkerregions.Itisalmostexclusivelylocatedinthepostsynapticdensityofneurons,[1]andisinvolvedinanchoringsynapticproteins.Itsdirectandindirectbindingpartnersincludeneuroligin,NMDAreceptors,AMPAreceptors,andpotassiumchannels.PSD-95isaexcellentMarkerforpostsynpaticmechanisms.

Image:PSD-95(green)andKv4.2(red)stainingofrathippocampalneurons.

Note:ThisantibodyhasbeendevelopedbyUCDavisunderagrantbyNIH.


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