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Neuromics/TRIM2/P41028/100 ug Blocking Peptide188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Neuromics/TRIM2/P41028/100 ug Blocking Peptide

Type:GoatIgG

 

Applications:IHC;WB;IP

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:PeptidewithsequenceDSGNHCFKVYRYLQ,fromtheCTerminusoftheTRIM2proteinsequenceaccordingtoNP_056086.2;NP_001123539.1

 

Picture

TRIMRINGfingerproteinTRIM2,aubiquitinligase,ishighlyexpressedinthenervoussystem.Itbindstoneurofilamentlightsubunit(NF-L)andregulatesNF-Lubiquitination.DeficienciesinTRIM2increasesNF-LlevelinaxonsandNF-L-filledaxonalswellingsincerebellum,retina,spinalcord,andcerebralcortex.

Image:TRIM2(dilution:6.3µg/ml)stainingofparaffinembeddedHumanCortex.SteamedantigenretrievalwithcitratebufferpH6,AP-staining.Notecytoplasmstaininginneuronalcellbodies.Protocol ondatasheet.

Thesedeficiencieseventuallyleadtoneurodegeneration,tremorsandataxia.ItisproposedthatTRIM2hasneuroprotectionproperties.


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