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ThisgeneisamemberoftheEPO/TPOfamilyandencodesasecreted,glycosylatedcytokinecomposedoffouralphahelicalbundles.Theproteinisfoundintheplasmaandregulatesredcellproductionbypromotingerythroiddifferentiationandinitiatinghemoglobinsynthesis.Thisproteinalsohasneuroprotectiveactivityagainstavarietyofpotentialbraininjuriesandantiapoptoticfunctionsinseveraltissuetypes.
Image: EPO-αHumanStructureandSequence.
References:
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2.Theefficacyofpreoperativeadministrationofasingledoseofrecombinanthumanerythropoietininpediatriccardiacsurgery. HeartSurgForum2007;10(2):E115-9.
3.Neurocognitivedysfunctionpost-cardiacsurgeryandtheneuroprotectiveeffectsoferythropoietin. CanJCardiovascNurs2007;17(2):5-8;quiz8-9,5.
4.[Pureredcellaplasiainpatientstreatedwithrecombinanterythropoietinforanemiaduetochronicrenaldisease] RinshoKetsueki2007May;48(5):391-6.
5.Erythropoietin,theFDA,andoncology. NEnglJMed2007Jun14;356(24):2448-51.
6.Docancercellsexpressfunctionalerythropoietinreceptors? NEnglJMed2007Jun14;356(24):2447.