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Neuromics/CXCR2/IL8 RB/MO15073/100 ug

Type:MouseIgG

 

Applications:IHC;FC;NB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:ProteinGPurified-AscitesFluid

 

Immunogen:HybridomaresultingfromthefusionofamousemyelomawithBcellsobtainedfromamouseimmunizedwithhumanCXCR2-transfectedNS0cells.

 

Picture

Chemokinereceptorsareseven-transmembranedomainG-proteincoupledreceptorsthatmediatethebiologicalactivitiesofchemokines.Mostofthesereceptorsexhibitpromiscuousbindingpropertieswherebyseveraldifferentchemokinessignalthroughthesamereceptor.Theyarenamedaccordingtothechemokinesubfamilytheybind.TherearecurrentlysixCXC-specificreceptorsdesignatedCXCR1toCXCR6,elevenCC-specificreceptorsdesignatedCCR1toCCR11,andoneCreceptor,XCR1.CX3CR1isthereceptorforfractalkine.

Image:  CXCR2 stainingof humanlymphnodes.CellswerestainedusingABC-HRP+AEC(red)andHaematoxylin(blue)counterstain.Itisrecommendedtoemployanavidin-biotinblockingstepandquenchendogenousperoxidase.


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