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Neuromics/IGFBP5/MO15091/500 ug

Type:MouseIgG

 

Applications:WB;E

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:M

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:ProteinGPurified-liquid

 

Immunogen:HybridomaresultingfromthefusionofamousemyelomawithBcellsobtainedfromaratimmunizedwithpurified,NS0-derived,recombinantmouseInsulin-likeGrowthFactorBindingProtein5(rmIGFBP-5).

 

Picture

Thesuperfamilyofinsulin-likegrowthfactor(IGF)bindingproteinsincludethesixhigh-affinityIGFbindingproteins(IGFBP)andseverallow-affinitybindingproteinsreferredtoasIGFBPrelatedproteins(IGFBP-rP).AllIGFBPsuperfamilymembersarecysteine-richproteinswithconservedcysteineresidues,whichareclusteredintheamino-andcarboxy-terminalthirdsofthemolecule.IGFBPsmodulatethebiologicalactivitiesofIGFproteins.SomeIGFBPsmayalsohaveintrinsicbioactivitythatisindependentoftheirabilitytobindIGFproteins.Post-translationalmodificationsofIGFBP,includingglycosylation,phosphorylationandproteolysis,havebeenshowntomodifytheaffinitiesofthebindingproteinstoIGF.

IGBP-5isimportanttodevelopment.Itcouldplayaroleincertaindevelopmentrelateddisorderslikemyotonicdystrophy-1andcancers.

Image:  IGFBP5 stainingof paraffin-embeddedhumanlivertissuesections. Tissueswerestainedusinganti-goatHRP-DABCellandTissueStainingKit(brown)andcounterstainedwithhematoxylin(blue).


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