
CD34isatypeItransmembraneglycophosphoproteinexpressedbyhematopoieticstem/progenitorcells(HSCs).
CD34mayalsostimulateproportionsofadulthumanHSCstodifferentiateintofull-fledgedneurons.Thismayopennewpossibilitiesforahigh-yieldproductionofneuronsfrombonemarrow.
Intumors,CD34isfoundinalveolarsoftpartsarcoma,preB-ALL(positivein75%),AML(40%),AML-M7(most),dermatofibrosarcomaprotuberans,gastrointestinalstromaltumors,giantcellfibroblastoma,granulocyticsarcoma,Kaposi’ssarcoma,liposarcoma,malignantfibroushistiocytoma,malignantperipheralnervesheathtumors,mengingealhemangiopericytomas,meningiomas,neurofibromas,schwannomas,andpapillarythyroidcarcinoma.
Image:CD34stainingofparaffin-embeddedhumancapillaryhemangioma.