Neuromics/FGF2, basic, Sf9/PR270142/2 ug

Acidicfibroblastgrowthfactorisamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivities,andareinvolvedinavarietyofbiologicalprocesses,includingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.Thisproteinfunctionsasamodifierofendothelialcellmigrationandproliferation,aswellasanangiogenicfactor.Itactsasamitogenforavarietyofmesoderm-andneuroectoderm-derivedcellsinvitro,thusisthoughttobeinvolvedinorganogenesis.
Threealternativelysplicedvariantsencodingdifferentisoformshavebeendescribed.Theheparin-bindinggrowthfactorsareangiogenicagentsinvivoandarepotentmitogensforavarietyofcelltypesinvitro.Therearedifferencesinthetissuedistributionandconcentrationofthese2growthfactors.

Image:FGF2, Sf9insectderived proteinstructureandsequence

References:

1.AcidicFGFenhancesfunctionalregenerationofadultdorsalroots.LifeSci2004Feb27;74(15):1937-43
2.LocallyreducedlevelsofacidicFGFleadtodecreasedexpressionof28-kdacalbindinandcontributetotheselectivevulnerabilityoftheneuronsintheentorhinalcortexinAlzheimersdisease.Neuropathology2001Sep;21(3):203-11
3.InfluenceofIN-1antibodyandacidicFGF-fibringlueontheresponseofinjuredcorticospinaltractaxonstohumanSchwanncellgrafts. JNeurosciRes1997Dec1;50(5):888-905
4.AcidicFGFregulationofhyperproliferationoffibroblastsinhumanautosomaldominantpolycystickidneydisease. BiochemMolMed1997Aug;61(2):178-91
5.Effectofbasic(FGF-2)andacidic(FGF-1)fibroblastgrowthfactorsonearlyhaemopoieticcelldevelopment. BrJHaematol1996Jun;93(4):772-82
6.AcidicFGFinducesNGFanditsmRNAintheinjuredneocortexofadultanimals.BrainResMolBrainRes1995Oct;33(1):1-6