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Neuromics/Ret/GT15002/100 ug

Type:GoatIgG

 

Applications:E;IHC;WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:RecombinantmouseRetextracellulardomain

 

Picture

TheGDNFfamilymembers(GDNF,neurturinandpersephin)signalthroughmulticomponentreceptorsthatconsistoftheRetreceptortyrosinekinaseandoneoffourglycosyl-phosphatidylinositol(GPI)-linkedligand-bindingsubunits(GFRalpha-1-4).GFRalpha-1,-2,and-4arethepreferredligand-bindingsubunitsforGDNF,neurturinandpersephin,respectively.TheRettyrosine-kinasereceptorisencodedbythec-retproto-oncogene.HumanandmouseRetshare83%aminoacidsequencehomology.

Mutationsinthisgeneareassociatedwiththedisordersmultipleendocrineneoplasia,typeIIA,multipleendocrineneoplasia,typeIIB,Hirschsprungdisease,andmedullarythyroidcarcinoma.Twotranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.

Image:Ret staining ofspermatagonialstemcells

Ret:CustomerDataandPublications


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