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Neuromics/ABCA1/MO13101/100 ul

Type:MouseIgG

 

Applications:WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:ProteinGPurified-liquid

 

Immunogen:50kDaN-terminalextracellularloopofABCA1(AA)

 

Picture[2]Picture

ByWesternblotmouseanti-ABCA1(MO13101;cloneHJ1)recognizesrat(leftimage),mouse(rightimage) andtoalesserextenthuman(leftimage) ABCA1. 

DavidHoltzmanandcolleaguesatWashingtonUniversityinSt.LouishaverecentlypublishedseveralpapersintheJournalofBiologicalChemistrydemonstratingtheroleofABCA1in ApoEregulationandthatanincreaseinABCA1maycauseadecreaseinamyloiddeposition.ThedatapresentedsuggestinthepapersbelowsuggestsacentralroleforABCA1inAlzheimersbiology,leadingtheauthorstospeculateABCA1asapotentialdrugtarget.  

WahrleSE,JiangH,ParsadanianM,LegleiterJ,HanX,FryerJD,KowalewskiT,andHoltzmanDM(2004).ABCA1isRequiredforNormalCentralNervousSystemApoELevelsandforLipidationofAstrocyte-secretedapoE.JBiol.Chem.279(39):40987.

WahrleSE,JiangH,ParsadanianM,HartmanRE,BalesKR,PaulSMandHoltzmanDM(2005).DeletionofAbca1IncreasesAbetaDepositioninthePDAPPTransgenicMouseModelofAlzheimerDisease.J.Biol.Chem.280(52):43236.

PleasenotethisantibodyalsoworksforWBinRabbitHippocampalTissue.

ABCA1:CustomerData andPublications


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