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Neuromics/Presenilin 2/RA18004/100 ul

Type:RabbitIgG

 

Applications:ICC;IHC;WB;IP

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;Pr;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:Peptidecorrespondingtoresiduessurroundingaminoacid330ofhumanpresenilin2

 

Picture

Presenilin-1(PS-1)andPresenilin-2(PS-2)areintegralmembraneproteinsthatcontainmultipletransmembranedomains.Botharepredominantlylocatedwithintheendoplasmicreticulum(ER)andearlyGolgiapparatus.Theyareprimarilyexpressedinneuronsandareubiquitouslyexpressedinthebrain.PS-1andPS-2areproteolyticallycleavedtogenerateanN-terminalfragment(NTF)andaC-terminalfragment(CTF).MutationsinthegeneforPresenilinmayplayanimportantroleinthepathologyofAlzheimersdisease.

Image:Presenilin2staininginparaffin-embeddedhumanbrain,showingbothnuclearandcytoplasmicproteinlocalization.DatacourtesyofCellSignalingTechnology,Inc.

Note;Immunohistochemistry,immunoprecipitation,immunocytochemistryandwesternblotprotocolsonDatasheet.


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