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Adipogen/AktI1/SYN1005M001/1 mg
MoreInformation
ProductDetails
SynonymsAktI1
ProductTypeChemical
Properties
FormulaC22H30N6
MW378.5
CAS473382-39-7
PurityChemicals≥95%
AppearanceSolid.
SolubilitySolubleinDMSO.
DeclarationManufacturedbySynKinase.
OtherProductDataTarget:AKT|KinaseGroup:AGC|Substrate:Serine-Threonine

ClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyFKCXKEHHZXEWGP-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
Thecompound(Akt-I-1)inhibitsonlyAkt1(IC(50)4.6µM)anddoesnotinhibitAKT2,orAKT3.Thecompoundisareversibleinhibitor,andexhibitsalinearmixed-typeinhibitionagainstATPandpeptidesubstrate.InadditiontoinhibitingkinaseactivityofAKT1isoform,AKT-I-1blockedthephosphorylationandactivationofAKT1byPDK1(phosphoinositide-dependentkinase1).Theinhibitorwasfoundtobecell-activeandtoblockphosphorylationofAktatThr308andSer473,reducethelevelsofactiveAktincells,blockthephosphorylationofknownAktsubstratesandpromoteTRAIL(tumour-necrosis-factor-relatedapoptosis-inducingligand)-inducedapoptosisinLNCapprostatecancercells.
ProductReferences
  1. Identificationandcharacterizationofpleckstrin-homology-domain-dependentandisoenzyme-specificAktinhibitors:S.F.Barnett,etal.;Biochem.J.385,399(2005)

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