Adipogen/Hypothemycin/BVT0067M001/1 mg

MoreInformation
ProductDetails
ProductType	Chemical
Properties
Formula	C₁₉H₂₂O₈
MW	378.4
CAS	76958-67-3
Source/HostChemicals	IsolatedfromPhomasp.
PurityChemicals	≥98%(HPLC)
Appearance	Whitetooff-whitesolid.
Solubility	SolubleinDMSOoracetone;insolubleinmethanolorwater.
Identity	Determinedby¹H-NMR.
Declaration	ManufacturedbyBioViotica.
InChiKey	SSNQAUBBJYCSMY-KNTMUCJRSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
Use/Stability	Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Antifungal.
Cytotoxicagainstsometumorcelllines,partlyattributedtoinhibitionofRas-induciblegenes.
InhibitsproliferationofmouseandhumanTcells.
ModulatesproductionofcytokinesduringTcellactivation.
FacilitatestheubiquitinylationprocessofcyclinD1.
Potentandselectivethreonine/tyrosine-specifickinase,MEKandotherproteinkinasesinhibitorinbothinvitroandinvivostudies.

ProductReferences

MetabolitesofpyrenomycetesXIII:Structureof(+)hypothemycin,anantibioticmacrolidefromhypomycestrichothecoides:M.S.R.Nair&S.T.Carey;TetrahedronLett.21,2011(1980)
Metabolitesofpyrenomycetes.XIV:Structureandpartialstereochemistryoftheantibioticmacrolideshypothemycinanddihydrohypothemycin:M.S.R.Nair,etal.;Tetrahedron37,2445(1981)
Revisedstructureandstereochemistryofhypothemycin:T.Agatsumaetal.;Chem.Pharm.Bull.41,373(1993)
Antitumorefficacyofhypothemycin,anewRas-signalinginhibitor:H.Tanaka,etal.;Jpn.J.CancerRes.90,1139(1999)
HypothemycininhibitstheproliferativeresponseandmodulatestheproductionofcytokinesduringTcellactivation:R.Camacho,etal.;Immunopharmacology44,255(1999)
Resorcylicacidlactones:naturallyoccurringpotentandselectiveinhibitorsofMEK:A.Zhao,etal.;J.Antibiot.52,1086(1999)
SuppressionofoncogenictransformationbyhypothemycinassociatedwithacceleratedcyclinD1degradationthroughubiquitin-proteasomepathway:H.Sonoda,etal.;LifeSci.65,381(1999)
Targetedcovalentinactivationofproteinkinasesbyresorcylicacidlactonepolyketides:A.Schirmer,etal.;PNAS103,4234(2006)
Chemistryandbiologyofresorcylicacidlactones:N.Winssinger,etal.;Chem.Commun.(Camb).1,22(2007),(Review)
TheresorcyclicacidlactoneHypothemycinselectivelyinhibitsthemitogen-activatedproteinkinasekinase-extracellularsignal-regulatedkinasepathwayincells:H.Fukazawa,etal.;Biol.Pharm.Bull.33,168(2010)

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